This is an action game in which players follow the story of Ellie and Joel on their continued struggle for survival in post-pandemic Wyoming. From a third-person perspective, players traverse through small towns, wilderness, and ruin environments, using a variety of weapons (e.g., rifles, pistols, explosives, blades) to kill infected mutants and human survivors in frenetic combat. Some sequences enable players to use stealth attacks against enemies—approaching from behind, slitting their throats. Players can also use explosives to set enemies on fire or blow enemies apart into limbs/bloody chunks of flesh. Cutscenes depict further instances of violence: a human captive bound and hung from a noose before being disemboweled; assailants beating a restrained woman's arm with a hammer; characters shot in the head with arrows; a man repeatedly pistol-whipped. The game contains some sexual content: a couple disrobing and briefly engaging in a sexual act; the couple is heard grunting/moaning as the screen turns black (depicted from the waist up with female toplessness). Some zombie creatures are depicted with exposed breasts and genitalia. One sequence depicts two characters smoking a marijuana joint in a room full of marijuana plants. The words “f**k” and “sh*t,” appear in the dialogue.
Five years after their dangerous journey across the post-pandemic United States, Ellie and Joel have settled down in Jackson, Wyoming. Living amongst a thriving community of survivors has allowed them peace and stability, despite the constant threat of the infected and other, more desperate survivors.
When a violent event disrupts that peace, Ellie embarks on a relentless journey to carry out justice and find closure. As she hunts those responsible one by one, she is confronted with the devastating physical and emotional repercussions of her actions.